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Description

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RAGE pathway: DAMP-induced altered cellular function, inflammatory cascade, and differentiated signaling responses Activation of the RAGE triggers multiple intracellular signaling pathways, including mitogen-activated protein (MAP) kinases (ERK 1/2, p38, SAPK/JNK), STAT3, Akt, and Rho GTPases (Rac1, Cdc42)