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Tissue-penetrating delivery of compounds and nanoparticles into tumors
Coupled with endogenous reactive oxygen species (ROS) generated as by-products of various cellular processes, strict regulation of antioxidants is critical to maintaining a balanced reduction/oxidation (redox) state
The trial met its primary endpoint, showing a biopsy-proven improvement in MASH after 48 weeks, without worsening of fibrosis stages F1, F2 and F3 (mild to moderate or advanced scarring)
Oxidative cell death in cancer: mechanisms and therapeutic opportunities, Cell Death & Disease 2024 15:8 , vol
Light protection: Both peptides contain Trp, which undergoes photodegradation under UV light
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