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5, SeNPs exert their anti-ferroptotic effects in renal tubular epithelial cells through a stepwise mechanism: they are first internalized into the cytoplasm via endocytosis, subsequently enriched within lysosomes, and then stimulate XBP1 expression to block I/R-induced excessive activation of NCOA4-mediated ferritinophagy, ultimately interrupting iron-dependent cell death cascades
Panizo S, Martnez-Arias L, Alonso-Montes C, Cannata P, Martn-Carro B, Fernndez-Martn JL, Naves-Daz M
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2024;38(8):e23791.[DOI] 98
