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Conflicting results were reported in further studies with large patient numbers, which failed to demonstrate an antioxidant or oxidant balance [74, 103]
One consistent pattern of pathology has emerged: there is a strong association of demyelination with proximity to CSF-containing spaces, including the subpial cortex, CSF-filled perivascular Virchow-Robin spaces (part of the brains glymphatic system
Our data are consistent with recent data generated in human umbilical vein endothelial cells such as inhibition of AKT and p38/MAPK pathways has antiangiogenic effects
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