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If the weight is coming off too quickly, you may need to downregulate a dose or perhaps switch to a medicine thats less potent. Siegel points out that the lower 4 mg retatrutide dose yielded a 19 percent body weight reduction, with a significantly lower rate of discontinuation, suggesting this may be a more tolerable option for many

Common microdosing approaches The following are the common microdosing approaches: Sustained low dose: Some individuals remain indefinitely on the initial starter dose, such as 0.25 mg of semaglutide weekly, and never exceed this dose

Use U-100 insulin syringes only as using other syringes can lead to incorrect volume and actual amount injected

I mentioned micro-dosing

In diabetes trials (SURPASS), patients lost an average of 712 kg (approximately 1525 pounds) over 40 weeks, depending on the dose achieved