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Abbreviations 5-HIAA: 5-hydroxyindoleacetic acid 5-HT: Serotonin 5-HT 2A/1A R: Serotonin 1/2A receptor 5-HTP: 5-Hydroxytryptophan AA: Amino acid AADC: Aromatic L-amino acid decarboxylase ACC: Anterior cingulate gyrus ADC: Agmatine decarboxylase ADHD: Attention deficit hyperactivity disorder ADP: Adenosine diphosphate AGM: Agmatine AGMAT: Agmatinase Amg: Amygdala ARR2: Beta-arrestin-2 ARG: L-Arginine ARG I/II: Arginase I/II ASD: Autism spectrum disorder ATP: Adenosine triphosphate BDNF: Brain-derived neurotrophic factor CAT: Catalase Cereb: Cerebellum CN: Caudate nucleus CNS: Central nervous system COMT: Catechol-O-methyltransferase CoQ: Coenzyme Q CREB: cAMP-response element binding protein Cyt c: Cytochrome c D D1/D2 R: Dopamine D1/2 receptor DA: Dopamine DAT: Dopamine transporter DBH: Dopamine beta-hydroxylase DDC: DOPA decarboxylase DMT: N, N-Dimethyltryptamine DRn: Dorsal raphe nucleus Drp1: Dynamin-related protein 1 EC: Entorhinal cortex ECC: Enterochromaffin cell ENS: Enteric nervous system ERK: Extracellular signal-regulated kinases ETC: Electron transport chain FAD/FADH 2 : Flavin adenine dinucleotide FC: Frontal cortex FDOPA: Fluorine-18-labelled fluorodopa FG: Fusiform gyrus Fis1: Mitochondrial fission 1 protein GABA: Gamma-aminobutyric acid GABA A1/A2/A3/B3 R: GABA A1/A2/A3/B3 receptor(s) GAD: Glutamic acid decarboxylase enzyme GI: Gastrointestinal GIT: Gastrointestinal tract Glu: Glutamate GPx: Glutathione peroxidase GR: Glutathione reductase GSH: Glutathione GSSG: Glutathione disulfide Hipp: Hippocampus HPA: 4-Hydroxyphenylacetaldehyde HVA: Homovanillic acid I V: Mitochondrial electron transport chain complex I - V IAA: Indoleacetic acid IBD: Inflammatory bowel disease IBS-D: Diarrhoea predominant IBS IBS: Irritable bowel syndrome INMT: Indolethylamine-N-methyltransferase L-DOPA: Levodopa L-Phe: L-Phenylalanine L-Trp: L-Tryptophan L-Tyr: L-Tyrosine m-TYR/3-MT: 3-Methoxytyramine MAO-A/B: Monoamine oxidase-A/B MDA: Malondialdehyde MET: Mesenchymal-epithelial transition factor MFN1/2: Mitofusin 1/2 MnSOD: Manganese superoxide dismutase mPTP: Mitochondrial permeability transition pore mRNA: Messenger RNA MSNs: Medium spiny neurons mtDNA: Mitochondrial DNA MTX2: Metaxin 2 NAc: Nucleus accumbens NAD + /NADH: Nicotinamide adenine dinucleotide NADP + /NADPH: Nicotinamide adenine dinucleotide phosphate NEFL: Neurofilament protein NMPEA: N-Methylphenethylamine NMTRP: N-Methyltryptamine NMTYR: N-Methyltyramine NST: Nigrostriatal pathway OCT: Octopamine ODC: Ornithine decarboxylase OPA1: Optic atrophy 1 ORN: Ornithine PAA: Phenylacetic acid PAH: Phenylalanine hydroxylase PAO: Polyamine oxidase PCC: Posterior cingulate cortex -PEA: -Phenethylamine PFC: Prefrontal cortex PHC: Parahippocampal cortex Pir: Piriform PNMT: Phenylethanolamine N-methyltransferase PPP: Platelet poor plasma Prx(SH) 2 /Prx-S 2 : Peroxiredoxin reduced/oxidised PrxR: Peroxiredoxin reductase Pu: Putamen PUT: Putrescine QH 2 : Dihydroxyquinone ROS: Reactive oxygen species SCFA: Short chain fatty acid SERT: Serotonin transporter SMOX: Spermine oxidase SNPs: Single nucleotide polymorphisms SOD1/2: Superoxide dismutase 1/2 SPD: Spermidine SPDS: Spermidine synthase SPM: Spermine SPMS: Spermine synthase SSAT: Spermidine/spermine N1-acetyltransferase STC: Superior temporal cortex SYN: Synephrine TA: Trace amine TAAR1/2/6/7: Trace amine associated receptor 1/2/6/7 TH: Tyrosine hydroxylase TH1-ir: Tyrosine hydroxylase 1 immunoreactive TPH1/2: Tryptophan hydroxylase 1/2 TPH-ir: Tryptophan hydroxylase immunoreactive TRP: Tryptamine Trx(SH) 2 /Trx-S 2 : Thioredoxin reduced/oxidised TrxR: Thioredoxin reductase r-TYR: R-Tyramine VMAT2: Vesicular monoamine transporter 2 VNTR: Variable number tandem repeat VPA: Valproic acid ZF: Zebrafish References Aaron E, Montgomery A, Ren X, Guter S, Anderson G, Carneiro AMD, Jacob S, Mosconi M, Pandey GN, Cook E, Veenstra-VanderWeele J