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GLP-1 medications also carry some serious (but rare) warnings: Potential risk of thyroid C-cell tumors (observed in rodent studies, unclear relevance in humans) Risk of gallbladder problems Pancreatitis (rare but documented) Hair loss (temporary, related to rapid weight loss rather than the drug itself) One notable advantage of GLP-1 medications: they do not cause cognitive dysfunction, do not carry teratogenicity warnings as severe as topiramate, and are not controlled substances

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Additionally, intraperitoneal administration of GLP-1 at supraphysiological doses elicited an anti-adipogenic effect in rats (72), making GLP-1 a potential target for obesity treatment

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