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Most importantly, they experience meaningful weight loss
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People who experienced significant wearing-off on semaglutide often find the effect more noticeable after switching to tirzepatide, not because tirzepatide is less effective, but because its shorter half-life creates a wider gap between peak and trough levels
Your sleep feels light or broken, and you wake up not feeling refreshed
They are probably misleadingly named and might be better termed GPX-like (Fig
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