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These therapies must not be antagonistic and ideally should exert synergist effects targeting concomitant abnormal cellular and molecular pathways that drive its pathogenesis (thereby expanding the biological response) and prevent compensatory pathways that can reduce the efficacy of a single drug [6, 9, 132]
Woltjer RL, Nghiem W, Maezawa I, Milatovic D, Vaisar T, Montine KS et al
Intracellular barriers to non-viral gene transfer
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