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In cultured cardiomyocytes, overexpression of GPX4 or iron chelation targeting Fe 2+ in mitochondria prevented DOX-induced ferroptosis, suggesting that DOX triggers ferroptosis in mitochondria [58]

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Sanyal AJ, Chalasani N, Kowdley KV et al (2010) Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis

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The current formulary-driven switch, in contrast, represents a payer-initiated formulary shift rather than a supply-side limitation