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Both deliver semaglutide, but the route and dosing differ
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Whereas GLP-1 monotherapy slightly reduced plasma aspartate aminotransferase (AST) levels compared with those in MK-801-treated mice, GLP-1MK-801 treatment did not affect plasma AST or alanine transaminase (ALT) levels (Extended Data Fig
The percent mediated was calculated as the (total effect direct effect) / total effect 100%, and the standard error (and, hence, the 95% CI) of the percent mediated was estimated using the delta method
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