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Laboratory studies have examined GHK-Cu's effects on the expression of growth factors including basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) in cell culture models, particularly at concentrations around 1 nM

For dosing context, see the tesamorelin/ipamorelin dosing guide

doi: 10.1186/s12967-023-04515-7 130 CroiaCAstorriEMurray-BrownWWillisABrokstadKASutcliffeNet al

Concomitant medications may also contribute to musculoskeletal symptoms

Nocturnal plasma melatonin profile and melatonin kinetics during infusion in status [PMID: 9209772] Laboratory literature summary: Nocturnal plasma melatonin profile and melatonin kinetics during infusion in status migrainosus