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What the SELECT Trial Mediation Analysis Revealed The most definitive clinical evidence that cardiovascular protection is not driven by weight loss comes from a prespecified analysis of the SELECT trial, which enrolled 17,604 patients with obesity and established cardiovascular disease but no diabetes
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The program is aimed at adults with a body mass index of 30 or higher, or 27 or higher with a weight-related condition like Type 2 diabetes, high blood pressure, or high cholesterol, per the official website
Bergmann NC, Davies MJ, Lingvay I, Knop FK
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