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Dr Madigan also expressed concern that the potential side effects of taking the drugs - which can include gastrointestinal problems like vomiting and diarrhoea, and in rare cases, gallbladder and kidney problems - may not have been widely discussed in the publicity surrounding Williams's announcement

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Curiously, the Na + cavity remains occluded, without an obvious exit pathway or solvent accessibility

In patients with HFpEF and obesity, both semaglutide (STEP-HFpEF) and tirzepatide (SUMMIT) significantly reduced cardiovascular death and worsening heart failure events, with concomitant improvements in quality of life and functional capacity [3,47]

2009;60 Suppl 7:191-196