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You YN, Moskowitz J, Chang GJ, Mork M, Rodriguez-Bigas M, Bednarski BK, Messick C, Tillman M, Skibber J, Nguyen S, Kopetz S , Vilar E
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GLP-1RAs reduced the symptoms of alcohol withdrawal, prevented acute alcohol consumption by activating the mesolimbic dopamine system, which, in turn, smoothed various forms of alcoholic behavior
Simultaneously, leptin drops and adiponectin increases, both indicators that the body is processing energy and fat more efficiently
Mechanistically, GLP-1R activation raises cAMP levels and triggers the PKA/CREB (cAMP-response element-binding protein) signal transduction pathway, which regulates various cellular processes [111]
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