extended the approach by presenting synNotch ligands on biomaterials, pointing to the possibility of material-guided secretion, while Synthetic Enzyme-Armed KillER Chimeric Antigen Receptor-T platforms demonstrated how engineered immune cells can conditionally secrete prodrug-activating enzymes within the tumor microenvironment 114,115
After ultracentrifugation at 200,000 g for 20 min at 4 C the resulting supernatants were used in the assays
It is produced exclusively through solid-phase peptide synthesis and appears as a white lyophilized powder in its research-grade form
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