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FIGURE 7 3.8 Results of liver NF-kB p65 and SIRT1 immunohistochemistry SIRT1 was strongly expressed and NF-kB p65 was weakly expressed in the control group (Figure 8a)
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However, insufficient efficacy in solid tumors and limited persistence in vivo remain key constraints to their broader application
After repeated IM administration of BPC157 at 100 g/kg for seven consecutive days, the plasma concentration versus time curve (Figure 1C) and pharmacokinetic parameters (Table 3) were similar to those observed after a single IM injection at a dose of 100 g/kg, except for a slight increase in C max and AUC 0t
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