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Prx and GPx require secondary enzymes and cofactors to function efficiently and regulate the cytoplasmic redox system (Chae et al., 1994)

Mechanical stressshaking, rapid injection, direct powder contactdisrupts this structure irreversibly

Depletion of glutathione

Among these patients, five mutations of the pyruvate dehydrogenase (E1) alpha subunit have been reported previously: H44R, R88S, G89S, R263G, and V389fs [67,68,69,70,71]