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Subsequent small studies have produced inconsistent findings
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Oxidative and Nitrosative Stress: When neurons metabolize too much glucose, it results in an overproduction of reactive oxygen species (ROS) and reactive nitrogen species (RNS)
In this regard, vitamin E is known to act synergistically with vitamin C to regenerate tocopheryl radicals, the oxidation product of alpha-tocopherol (125)
For Pycnogenol constituents and metabolites, interactions with some specific structures, such as matrix proteins (21), erythrocyte membranes (22) and human albumin (23) were characterized in vitro
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