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This comprehensive, systems-oriented viewpoint promotes fundamental shifts towards proactive, mechanism-focused initiatives that enhance and will continue to advance our comprehension of positive, healthy aging, as outlined in Table 4, which highlights critical knowledge gaps and outlines actionable future research directions for GLP-1 RAs in promoting healthy aging
PI3K activates protein kinase B (Akt), which inactivates several important substrate proteins, such as glycogen synthase kinase 3 (GSK-3) 18 and forkhead box O, 19 and activates mammalian target of rapamycin (mTOR)
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