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[10] The first amylin analogue to reach the clinic, pramlintide, demonstrated that the pathway could be drugged, but native-style amylin analogues are short-acting and were used as multiple-daily injections, which limited their appeal for weight management
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The C-terminal is conserved among all PDEs, except for PDE6, showing 18%46% sequence similarity (Figure 1)
The increased expression of CBS lowers the concentration of Hcy and therefore lowers the rate of the MS reaction
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