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It was first characterized by Predrag Sikiric and colleagues at the University of Zagreb in the early 1990s, and a 2025 literature and patent review cataloged its effects across gastrointestinal, musculoskeletal, and neural models
MRS work at 3 Tesla (3T) from one research group demonstrated elevated levels of ventricular lactate in cerebrospinal fluid (CSF) [14,15,16,17], as well as a reduction in the major endogenous free radical scavenger, glutathione (GSH) [16, 18]
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