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Mean HbA1c reduction: CagriSema: 2.2%, Semaglutide: 1.8%, and Cagrilintide: 0.9%

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Because amylin analogs are cleared in part renally and the postprandial glucose effect intersects with diabetes therapy, use in people with kidney impairment or on other glucose-lowering drugs warrants specific scrutiny a topic examined separately in the analysis of cagrilintide safety in chronic kidney disease