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Disease development is not entirely explained by genetic predisposition, so other factors have been identified as potential players, such as early exposure to childhood viruses and altered intestinal bacterial composition [58]
Mansour HM, Mohamed AF, El-Khatib AS, Khattab MM
First-generation pramlintide demonstrated proof-of-concept but suffered from short half-life requiring multiple daily injections and producing only 2-4% weight loss
Aytac S et al
PubMed PMID: 23163594
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