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PKA causes membrane depolarization and eventually Ca2+ release via the Inositol Triphosphate pathway (IP3)

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Both are dominated by dose-related gastrointestinal effects (nausea, diarrhea, constipation)

Adding this duo to Retatrutide creates a three-pronged approach: metabolic transformation from the triple agonist, localized repair from BPC-157, and systemic healing from TB-500