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First, the experimental design did not include a remogliflozin-only group, which limited our ability to distinguish the direct effects of remogliflozin from its interaction with TAA-induced pathology or potential vehicle effects

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The 2025 NEJM trial comparing tirzepatide directly against semaglutide showed 20.2% versus 13.7% weight loss over the same treatment period

doi: 10.3389/fendo.2019.00101 58 AckermannAMMossNGKaestnerKH