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Activation of rodent AP and NTS Calcr neurons acutely reduces food intake and body weight 12,13 , while AP lesions attenuate acute amylin-induced suppression of food intake 9
15.6% with semaglutide Trial REDEFINE 1 (NEJM 2025) Duration 68 weeks Population Obesity, no T2D (n=3,417) Mean Weight Loss 11.8% cagrilintide alone
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Regular B12 supplementation is necessary to maintain optimal levels and prevent deficiency from occurring again
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