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In some analyses, early initiation is associated not merely with neutral cardiovascular outcomes but with active cardiovascular benefit, a finding that aligns with the known role of estrogen in maintaining vascular elasticity, endothelial function, and lipid metabolism [12]

While there is no direct contraindication, the combination increases the need for diligent hydration and professional monitoring of your blood pressure and kidney health

doi: 10.1016/j.tips.2009.08.003 32 JungraithmayrWEnzN

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Therefore, ensure to pick up a product from good manufacturers that have good quality control measures