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111,112 Taking a water-soluble CoQ10 (160 mg) plus other nutrients (B vitamins, vitamin E [36 mg], choline [100 mg], melatonin [1 mg], ginkgo phytosome [80 mg], and milk protein hydrolysate [150 mg]) appeared to protect against hearing damage and tinnitus in a pilot trial that included 26 cancer patients being treated with cisplatin (Platinol), a chemotherapy agent known to have ototoxicity
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Innate Repair Receptor (IRR) Activation: ARA-290 binds selectively to the IRR (EPOR/CR heteromer), activating the full IRR-mediated tissue protection cascade: JAK2/STAT3, PI3K/Akt, and MAPK/ERK signalling, producing anti-apoptotic, anti-inflammatory, and regenerative downstream effects across neural, vascular, and metabolic cell types
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