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[58] demonstrated that the sumoylated PKM2 was sorted into ectosomes and subsequently transferred into neighboring cells

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The increase in EBV latent cells also leads to an increase in evasion mechanisms by decreasing the activation and cytotoxic response of EBNA-1-specific CD4 T cells through IL-10 release, Treg recruitment, and the release of EBV miRNA contained in exosomes

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The part that doesnt get enough airtime is the operational complexity this introduces: - Dose reproducibility at micro volumes - Device variability and aging behavior - Extractables / adsorption risks - Cleaning, sterility, and cross-contamination strategy - Human factors becoming part of product performance At that point, youre no longer optimizing a molecule

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