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Up to 40 percent of weight lost on semaglutide can come from lean mass without deliberate protein intake and resistance training

1 Despite these constraints, the commercial consequence has been significant: Medicare logged $27.5 billion in gross GLP-1 spending across 21.8 million claims in 2024, entirely under FDA-approved indications other than obesity

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The data supported reduced-frequency dosing as a viable maintenance strategy patients maintained most of their weight loss at lower dosing frequency

It is one of the most common ongoing side effects, persisting beyond the escalation period for some patients