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These results suggest that GLP1R agonists in combination with a calcitonin receptor agonist, is able to show even larger decreases in body weight than typical GLP1R agonists, within a shorter time and with a more favourable side effect profile

doi: Kim ED, Crosnoe L, Bar-Chama N, Khera M, Lipshultz LI

The dose is escalated over 16 weeks, starting at 0.25mg and increasing to a maintenance dose of 2.4mg

Yamazaki T, Yamada S, Ohshio K, Sugamata M, Morita Y (2022) Lactobacillus paracasei KW3110 prevents inflammatory-stress-induced mitochondrial dysfunction in mouse macrophages

Further studies revealed that DPP4 acts as a binding protein for adenosine deaminase (ADA) and serves as a T cell activation marker, transmitting co-stimulatory signals upon ADA stimulation