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Methodological consideration on peroxidation biomarkers and total antioxidant capacity All the reviewed studies used old markers, such as peroxides, dienes, TBARS or MDA, that are progressively being replaced by new one isoprostanes [71] and all studies measured TAC by using a single assay, which imposes the chemical limitations of that assay [72, 73]

doi: 10.1507/endocrj.ej12-0074 12 FintiniDGrugniGBrufaniCBocchiniSCappaMCrinA

Mitamura T, Sakamoto S et al

Furthermore, this improvement was not permanent and, after six months of administration, only one (6.2%) participant continued to experience skin tone reduction