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The FDA found no clinical studies or publicly available human exposure data for administered MOTS-c, no adequate toxicology, uncertain characterisation and unresolved immunogenicity.[6] The same caution applies to a large range of other non-GLP-1-related peptides that are promoted well beyond the supporting human evidence and in the absence of adequate safety data.[8] Unapproved peptides are not included in the Australian Register of Therapeutic Goods and have not been evaluated by the TGA for safety, quality or effectiveness

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We generally advise against it if you have any of the following: History of Medullary Thyroid Cancer: The drug is a GLP-1 receptor agonist, which has been shown to cause recurrences of thyroid tumors in patients with a history of it

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