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The peptide calculator handles the math
2012 to 2020
The copper ion binds at the histidine residue to form a stable Cu(II) chelate (sometimes written GHK-Cu or [Cu-GHK])
According to the NICE Clinical Knowledge Summary (CKS) and the British National Formulary (BNF) , the standard treatment for B12 deficiency without neurological symptoms involves: Hydroxocobalamin 1 mg intramuscularly three times weekly for two weeks Followed by maintenance doses of 1 mg every three months For patients with neurological symptoms (such as paraesthesia, numbness, cognitive changes, or gait disturbances), more intensive treatment is required: Hydroxocobalamin 1 mg intramuscularly on alternate days until no further improvement occurs Followed by 1 mg every two months for maintenance Pernicious anaemia , an autoimmune condition where the body cannot produce intrinsic factor, requires lifelong treatment
doi: 10.1536/ihj.19-327 39 ZhouYHeXChenYHuangYWuLHeJ
