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One path offers pharmaceutical suppression with significant side effects and dependency risks
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GLP-1 receptor agonists like semaglutide and tirzepatide work by slowing digestion and reducing appetite
Whilst metreleptin monotherapy supports weight loss in obese individuals, it is not clinically meaningful with a mean 1.5 kg additional weight loss over 24 weeks noted in a previous trial [87]
Selenium toxicity results in loss of hair and nails, lesions of the skin, nervous system, and possible teeth
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