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The FDA approval of the first oral GLP-1 for weight loss in December 2025-Novo Nordisk's once-daily semaglutide pill-represents a watershed moment for the category [3]
It promotes tissue repair and has anti-inflammatory properties
When your body has the nutrients it needs, everything works betteryour mind, your mood, and your energy
Most peptides described here are not approved by the FDA for treating autoimmune conditions
GLP-1 is an incretin hormone that stimulates insulin secretion in a glucose-dependent manner, reducing hypoglycaemia risk The hormone slows gastric emptying and suppresses appetite through receptors in the pancreas, brain, and gastrointestinal tract GLP-1 receptor agonists (semaglutide, liraglutide, dulaglutide) are MHRA-approved for type 2 diabetes and weight management Common side effects include nausea, vomiting, and diarrhoea due to delayed gastric emptying and altered gut motility Patients should seek urgent medical attention for severe abdominal pain with persistent vomiting, as this may indicate pancreatitis GLP-1 medications do not directly impair digestive enzyme production, and routine enzyme supplementation is not clinically indicated Table of Contents What Does GLP-1 Stand For
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