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As detailed in Table 2, while relatively straightforward targeted delivery applications have advanced to late preclinical or early clinical trials, systems designed for complex active interventions (e.g., microsuturing, ablation) remain largely at the in vitro proof-of-concept stage

Individuals noticing initial thinning within the past five years, particularly affecting the crown region, match the clinical profile most responsive to treatment

doi:10.3181/0703-MR-67

However, it is unsafe for pregnant or breastfeeding women, as it can cause serious congenital disabilities and developmental issues in babies