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PubMed 19
Mechanistically, alterations in gut microbial metabolites such as SCFAs could affect the integrity of the BBB, induce systemic endotoxemia, and activate microglia so as to impact disease progression
The psychological aspect of this disorder makes it difficult to treat, as patients may feel ashamed or embarrassed about their behavior and avoid help from others
The continuous systemic inflammation generated by this vascular damage further depletes the body's already compromised antioxidant reserves, perpetuating the cycle of chronic illness and making recovery incredibly difficult without targeted biochemical intervention
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