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The cellular ratio of BH 4 /BH 2 affects eNOS uncoupling and is implicated in the pathophysiology of EC dysfunction [137]
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l-C arnitine , a micronutrient composed of essential AAs (i.e., lysine and methionine), is a cofactor that converts long-chain free fatty acids to acyl-carnitine and transfers these metabolites into the mitochondrial matrix 639
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