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These drugs are blockbusters because they promise to solve a medical problem that is also a cultural problem how to cure the moral crisis of fat bodies that refuse to get and stay thin. In her piece, McMillan Cottom makes mention of diabetes and the murky category of prediabetes, but her discussion dwells primarily on what she sees as the drugs cultural implications: the way they function as a shorthand for our coded language of shame, stigma, status and bias around fatness. McMillan Cottoms distinction between the medical problem and cultural problem of obesity is a common theme of the Ozempic coverage
Note: Participants in the STEP-1 trial were patients with obesity
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Centrally, IRS1 dysfunction is associated with cognitive decline in AD [141]
