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As well as endogenous GLP-1,GLP-1 receptor agonists also have numerous other effects such as promoting weight loss, deceleration of gastric emptying, lowering blood pressure (systolic and diastolic), and lowering total cholesterol ( Figure 1
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Constipation due to decreased gastric motility is one of the most experienced side effects of GLP-1 drugs
The individual peptide components are produced using controlled solid-phase peptide synthesis (SPPS) and purified through high-performance liquid chromatography (HPLC)
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