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Mechanism of Action Comparison# Retatrutide# Retatrutide (LY3437943) is a 39-amino acid peptide that simultaneously activates three metabolically important receptors: GLP-1 receptor : Enhances glucose-dependent insulin secretion, suppresses glucagon release, slows gastric emptying, and promotes central satiety signaling GIP receptor : Potentiates insulin secretion, may improve beta-cell function, and contributes to adipose tissue metabolism Glucagon receptor : Increases hepatic glucose output acutely but chronically promotes hepatic fat oxidation, thermogenesis, and energy expenditure The glucagon receptor component distinguishes retatrutide from all other approved or late-stage metabolic peptides
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Epithalon (also known as Epitalon or Epithalone) is a synthetic tetrapeptide bioregulator consisting of four amino acids: alanine, glutamic acid, aspartic acid, and glycine (Ala-Glu-Asp-Gly)
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Most clinical applications use 600-2,400 mg/day [9][18][20]
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