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The goal is progressive resistance, not punishment
Excessive caffeine intake (over 500mg daily) may also increase insulin resistance, which can negatively impact blood sugar regulation
B12 supplementation is particularly relevant because GLP-1 agonists can reduce B12 absorption over time
While tirzepatide is not primarily eliminated through the kidneys, the gastrointestinal effects of the medication, including potential nausea, vomiting, and diarrhea, could lead to dehydration and electrolyte imbalances that may be particularly problematic in patients with compromised kidney function
Labrecque J et al
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