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Epigenetic reprogramming in cancer drug resistance and combating strategies Phenotypic and epigenetic reprogramming Epigenetic regulation, which governs heritable yet reversible changes in gene expression without altering the underlying DNA sequence, has emerged as a pivotal driver of therapeutic resistance across cancer types (Fig

Another option is to slowly taper over about three to six months while reinforcing lifestyle habits

[1] [3] For chronic weight management (Zepbound) , eligibility criteria include: Adults with BMI 30 kg/m (obesity), OR Adults with BMI 27 kg/m (overweight) with at least one weight-related comorbid condition such as hypertension, type 2 diabetes, or dyslipidemia Patients must be willing to engage in lifestyle modifications including reduced-calorie diet and increased physical activity