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The weight loss achieved by CagriSema (-20.4% at 68 weeks) is comparable to that reported with the dual glucose-dependent insulinotropic polypeptide (GIP)/GLP-1 receptor agonist tirzepatide (-20.9% with the 15-mg dose at 72 weeks in SURMOUNT-1) [14]
Cell 82 , 22672297 (2022)
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In this trial, CSF samples were taken, showing that the drug was able to cross the BBB and that 12 weeks after the trial had stopped, there was no drug present in the CSF anymore
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