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Lysosomal depletion and accumulation of autophagosomes are observed in the postmortem brain samples from PD patients, suggestive of defective autophagic clearance." Accumulation of inorganic mercury in lower motor neurons of mice (1992, B
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These strategies enhance intracellular drug delivery while reducing premature drug leakage in systemic circulation ( 3 Types of next-generation nanoparticles for cancer therapy 3.1 Lipid-based nanoparticles: liposomes, solid lipid nanoparticles, nanostructured lipid carriers Lipid-based nanoparticles (LNPs) are multifunctional nanocarriers employed in medical research and pharmacology for encapsulating therapeutic agents, ensuring drug protection, enhancing solubility, facilitating targeted delivery, and optimizing bio distribution (Figure 1) ( FIGURE 1 Nanoemulsions are colloidal formulations employed to encapsulate hydrophobic pharmaceuticals, thereby mitigating adverse effects
