This guidance specifically notes that patients may not readily disclose off-label aesthetic use of these medications, highlighting the importance of comprehensive medication histories [45]
For example, the SELECT trial showed a 20% improvement in major cardiovascular events (i.e., heart attacks, strokes, and deaths from those cases) in adults on weekly semaglutide who were overweight or obese (without diabetes) and with preexisting cardiovascular disease, as well as an improvement in all-cause mortality of 19%
Diabetes 59:479485 Schfer SA, Mssig K, Staiger H et al (2009) A common genetic variant in WFS1 determines impaired glucagon-like peptide-1-induced insulin secretion
What percentage of GLP-1 patients develop gastroparesis symptoms
Lifestyle and Dietary Considerations While GLP-1 therapy can be highly effective in managing blood sugar and promoting weight loss, it is not a substitute for healthy lifestyle choices