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Individual response varies considerably, with some participants experiencing meaningful fat loss while others showed minimal changes
An earlier 12-week trial in 300 obese adults produced a genuine positive signal the 1 mg daily dosing arm showed a statistically significant 2.8 kg mean weight loss versus 0.8 kg in the placebo group and that result is what justified moving into the larger Phase IIb trial
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Clinically, B12 shots are often used to treat confirmed deficiency, neurological symptoms, or anemia related to low B12 levels
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