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Moreover, we also observed a significant reduction in the weight of the cisplatin + RSL3 tumours when compared with the vehicle-treated group at the end point (Fig

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The decreased reproductive performance of SLC7A11 knockout male mice was supported by a high proportion of immature spermatozoa in the cauda epididymis, although there were no significant differences in cysteine and GSH levels in the testis compared to controls, suggesting GSH synthesized by xCT is considered to be an important antioxidant [76]